GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs6951245 | 1 | rs78896566 | chr7:1080182 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.41 | 1.33E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs12220238 | 1 | rs7897778 | chr10:75916105 | ADK | chr10:75910965-76469059:+ | 0.28 | 4.25 | 2.74E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs7904207 | chr10:75884474 | ADK | chr10:75910965-76469059:+ | 0.3 | 4.63 | 5.07E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs78153629 | 1 | rs79044944 | chr15:40676285 | C15orf23 | chr15:40674922-40686488:+ | 0.33 | 5.69 | 2.51E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs12220238 | 1 | rs7905536 | chr10:75997209 | ADK | chr10:75910965-76469059:+ | 0.27 | 4.16 | 3.93E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs7907801 | chr10:75976638 | ADK | chr10:75910965-76469059:+ | 0.32 | 4.84 | 1.9E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs7909664 | chr10:75869754 | ADK | chr10:75910965-76469059:+ | 0.27 | 4.1 | 5.01E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs7909915 | chr10:75960942 | ADK | chr10:75910965-76469059:+ | 0.31 | 4.71 | 3.41E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs7916697 | 1 | rs7916697 | chr10:69991853 | PBLD | chr10:70042417-70092684:- | -0.25 | -4.43 | 1.21E-5 | Optic disc area |
| BLCA | cis | rs56322409 | 1 | rs7917792 | chr10:97365627 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.97 | 1.03E-6 | Blood metabolite levels |
| BLCA | cis | rs1577917 | 1 | rs791856 | chr6:86681841 | SNHG5 | chr6:86386726-86388451:- | 0.54 | 9.72 | 4.2E-20 | Response to antipsychotic treatment |
| BLCA | cis | rs2143950 | 1 | rs79199019 | chr14:35581125 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 4.24 | 2.8E-5 | Atopic dermatitis |
| BLCA | cis | rs7927771 | 1 | rs7927771 | chr11:47781306 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.58 | 4.59E-8 | Subjective well-being |
| BLCA | cis | rs950169 | 1 | rs79318564 | chr15:84786150 | LOC388152 | chr15:84867600-84898920:- | -0.28 | -4.83 | 1.94E-6 | Schizophrenia |
| BLCA | cis | rs6951245 | 1 | rs79327308 | chr7:1108141 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.48 | 1.0E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |